There have been several spin-offs over the years, including:
- Pardon the Expression, a sitcom featuring Arthur Lowe as Leonard Swindley, a clothing store manager who left the parent show in 1965, but appeared in two series and 36 episodes of this spin-off between June 1965 and June 1966. Pardon the Expression itself had its own spin-off, Turn Out the Lights, which ran for one series and six episodes between January and February 1967, also featuring Lowe as Swindley.
- Albion Market was intended as a sister soap to Coronation Street, set in Weatherfield's undercover market, but only ran for one year (between August 1985 and August 1986) and 100 episodes.
- The Brothers McGregor, a sitcom set in Liverpool featuring two characters who had appeared in one episode of Coronation Street (Eddie Yeats and Marion Willis's engagement, May 1982). The sitcom ran for four series and 26 episodes between September 1985 and August 1988, but the two leads were not the same actors who's played the wheeler-dealer brothers in the parent show. In Coronation Street, Wesley and Cyril were played by Carl Chase and Tony Osoba, whereas in the spin-off, they were played by Philip Whitchurch and Paul Barber.